Showing posts with label drugs overdose and its treatment. Show all posts
Showing posts with label drugs overdose and its treatment. Show all posts

Thursday, 1 June 2017

Scabies symptom casuse diagnoses and treatment by drugs

DEFINITION of scabies

Scabies is an itchy skin condition caused by a tiny burrowing mite called Sarcoptes scabiei. The presence of the mite leads to intense itching in the area of its burrows. The urge to scratch may be especially strong at night.

Scabies is contagious and can spread quickly through close physical contact in a family, child care group, school class or nursing home. Because of the contagious nature of scabies, doctors often recommend treatment for entire families or contact groups to eliminate the mite.

Take heart in that scabies is readily treated. Medications applied to your skin kill the mites that cause scabies and their eggs, although you may still experience some itching for several weeks.

SYMPTOMS

Scabies signs and symptoms include:

Itching, often severe and usually worse at nightThin, irregular burrow tracks made up of tiny blisters or bumps on your skin

The burrows or tracks typically appear in folds of your skin. Though almost any part of your body may be involved, in adults scabies is most often found:

Between fingersIn armpitsAround your waistAlong the insides of wristsOn your inner elbowOn the soles of your feetAround breastsAround the male genital areaOn buttocksOn kneesOn shoulder blades

In children, common sites of infestation include the:

ScalpFaceNeckPalms of the handsSoles of the feet

When to see a doctor

Talk to your doctor if you have signs and symptoms that may indicate scabies.

Many skin conditions, such as dermatitis or eczema, are associated with itching and small bumps on the skin. Your doctor can help determine the exact cause and ensure you receive proper treatment. Bathing and over-the-counter preparations won't eliminate scabies.

CAUSES

The eight-legged mite that causes scabies in humans is microscopic. The female mite burrows just beneath your skin and produces a tunnel in which it deposits eggs. The eggs hatch in three to four days, and the mite larvae work their way to the surface of your skin, where they mature and can spread to other areas of your skin or to the skin of other people. The itching of scabies results from your body's allergic reaction to the mites, their eggs and their waste.

Close physical contact and, less often, sharing clothing or bedding with an infected person can spread the mites.

Dogs, cats and humans all are affected by their own distinct species of mite. Each species of mite prefers one specific type of host and doesn't live long away from that preferred host. So humans may have a temporary skin reaction from contact with the animal scabies mite. But people are unlikely to develop full-blown scabies from this source, as they might from contact with the human scabies mite.

COMPLICATIONS

Vigorous scratching can break your skin and allow a secondary bacterial infection, such as impetigo, to occur. Impetigo is a superficial infection of the skin that's caused most often by staph (staphylococci) bacteria or occasionally by strep (streptococci) bacteria.

A more severe form of scabies, called crusted scabies, may affect certain high-risk groups, including:

People with chronic health conditions that weaken the immune system, such as HIV or chronic leukemiaPeople who are very ill, such as people in hospitals or nursing facilitiesOlder people in nursing homes

Crusted scabies tends to be crusty and scaly, and cover large areas of the body. It's very contagious and can be hard to treat.

PREPARING FOR YOUR APPOINTMENT

Make an appointment with your family doctor or pediatrician if you or your child has signs and symptoms common to scabies.

Here's some information to help you get ready for your appointment, and know what to expect from your doctor.

Information to gather in advance

List any signs or symptoms you or your child has had, and for how long.List any possible sources of infection, such as other family members who have had a visible or itchy rash.Write down key medical information, including any other health problems and the names of any medications you or your child is taking.Write down questions you want to be sure to ask your doctor.

Below are some basic questions to ask your doctor about scabies.

What is the most likely cause of these signs and symptoms?Are there any other possible causes?What treatment approach do you recommend?How soon do you expect symptoms to improve with treatment?When will you see me or my child to determine whether the treatment you've recommended is working?Are there any home remedies or self-care steps that could help relieve symptoms?Am I or my child contagious? For how long?What steps should be taken to reduce the risk of infecting others?

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over any points you want to talk about in-depth. Your doctor may ask:

What signs and symptoms have you noticed?When did you first notice these signs and symptoms?Have these signs and symptoms gotten worse over time?If you or your child has a visible rash, what parts of the body are affected?Has anyone else with whom you have frequent, close contact had a rash, an itch or both within the last several weeks?Are you currently pregnant or nursing?Are you or your child currently being treated or have you recently been treated for any other medical conditions?What medications are you or your child currently taking, including prescription and over-the-counter drugs, vitamins and supplements?Is your child in child care?

What you can do in the meantime

In the time leading up to your appointment, try at-home and over-the-counter (OTC) remedies to help reduce itching. Cool water, antihistamines and calamine lotion may provide some relief. Ask your doctor what OTC medications and lotions are safe for your baby or child.

TESTS AND DIAGNOSIS

To diagnose scabies, your doctor examines your skin, looking for signs of mites, including the characteristic burrows. When your doctor locates a mite burrow, he or she may take a scraping from that area of your skin to examine under a microscope. The microscopic examination can determine the presence of mites or their eggs.

TREATMENTS AND DRUGS

Scabies treatment involves eliminating the infestation with medications. Several creams and lotions are available. You usually apply the medication over all your body, from your neck down, and leave the medication on for at least eight hours. A second treatment is needed if new burrows and rash appear.

Because scabies spreads so easily, your doctor may recommend treatment for all family members and other close contacts, even if they show no signs of scabies infestation.

Medications commonly prescribed for scabies include:

Permethrin 5 percent (Elimite). Your doctor may recommend that you apply this cream — which contains chemicals that kill scabies mites and their eggs — twice, with a week or so between each application. Permethrin is generally considered safe for children and adults of all ages, including women who are pregnant or nursing.Lindane. This medication — also a chemical treatment — is available as a cream, lotion and shampoo. This medication isn't safe for children younger than age 2 years, women who are pregnant or nursing, or people with weakened immune systems.Crotamiton (Eurax). This nonchemical medication is applied once a day for two to five days. Your doctor may recommend it if your baby has scabies.

Although these medications kill the mites promptly, you may find that the itching doesn't stop entirely for several weeks.

Doctors sometimes prescribe the oral medication ivermectin (Stromectol) for people with altered immune systems, for people who have crusted scabies, or for people who don't respond to the prescription lotions and creams.

LIFESTYLE AND HOME REMEDIES

To prevent re-infestation and to prevent the mites from spreading to other people, take these steps:

Clean all clothes and linen. Use hot, soapy water to wash all clothing, towels and bedding you used at least three days before treatment. Dry with high heat. Dry-clean items you can't wash at home.Starve the mites. Consider placing items you can't wash in a sealed plastic bag and leaving it in an out-of-the-way place, such as in your garage, for a couple of weeks. Mites die if they don't eat for a week. caused by a tiny burrowing mite called Sarcoptes scabiei. The presence of the mite leads to intense itching in the area of its burrows. The urge to scratch may be especially strong at night.

Scabies is contagious and can spread quickly through close physical contact in a family, child care group, school class or nursing home. Because of the contagious nature of scabies, doctors often recommend treatment for entire families or contact groups to eliminate the mite.

Take heart in that scabies is readily treated. Medications applied to your skin kill the mites that cause scabies and their eggs, although you may still experience some itching for several weeks.

SYMPTOMS

Scabies signs and symptoms include:

Itching, often severe and usually worse at nightThin, irregular burrow tracks made up of tiny blisters or bumps on your skin

The burrows or tracks typically appear in folds of your skin. Though almost any part of your body may be involved, in adults scabies is most often found:

Between fingersIn armpitsAround your waistAlong the insides of wristsOn your inner elbowOn the soles of your feetAround breastsAround the male genital areaOn buttocksOn kneesOn shoulder blades

In children, common sites of infestation include the:

ScalpFaceNeckPalms of the handsSoles of the feet

When to see a doctor

Talk to your doctor if you have signs and symptoms that may indicate scabies.

Many skin conditions, such as dermatitis or eczema, are associated with itching and small bumps on the skin. Your doctor can help determine the exact cause and ensure you receive proper treatment. Bathing and over-the-counter preparations won't eliminate scabies.

CAUSES

The eight-legged mite that causes scabies in humans is microscopic. The female mite burrows just beneath your skin and produces a tunnel in which it deposits eggs. The eggs hatch in three to four days, and the mite larvae work their way to the surface of your skin, where they mature and can spread to other areas of your skin or to the skin of other people. The itching of scabies results from your body's allergic reaction to the mites, their eggs and their waste.

Close physical contact and, less often, sharing clothing or bedding with an infected person can spread the mites.

Dogs, cats and humans all are affected by their own distinct species of mite. Each species of mite prefers one specific type of host and doesn't live long away from that preferred host. So humans may have a temporary skin reaction from contact with the animal scabies mite. But people are unlikely to develop full-blown scabies from this source, as they might from contact with the

TESTS AND DIAGNOSIS

To diagnose scabies, your doctor examines your skin, looking for signs of mites, including the characteristic burrows. When your doctor locates a mite burrow, he or she may take a scraping from that area of your skin to examine under a microscope. The microscopic examination can determine the presence of mites or their eggs.

TREATMENTS AND DRUGS

Scabies treatment involves eliminating the infestation with medications. Several creams and lotions are available. You usually apply the medication over all your body, from your neck down, and leave the medication on for at least eight hours. A second treatment is needed if new burrows and rash appear.

Because scabies spreads so easily, your doctor may recommend treatment for all family members and other close contacts, even if they show no signs of scabies infestation.

Medications commonly prescribed for scabies include:

Permethrin 5 percent (Elimite). Your doctor may recommend that you apply this cream — which contains chemicals that kill scabies mites and their eggs — twice, with a week or so between each application. Permethrin is generally considered safe for children and adults of all ages, including women who are pregnant or nursing.Lindane. This medication — also a chemical treatment — is available as a cream, lotion and shampoo. This medication isn't safe for children younger than age 2 years, women who are pregnant or nursing, or people with weakened immune systems.Crotamiton (Eurax). This nonchemical medication is applied once a day for two to five days. Your doctor may recommend it if your baby has scabies.

Although these medications kill the mites promptly, you may find that the itching doesn't stop entirely for several weeks.

Doctors sometimes prescribe the oral medication ivermectin (Stromectol) for people with altered immune systems, for people who have crusted scabies, or for people who don't respond to the prescription lotions and creams.

Friday, 14 April 2017

drugs Overdose and poisoning and its treatment

drugs Overdose and poisoning

Definition 

Acute poisoning may result from accidental self ingestion,
deliberate self-harm or medical error or when a parson  cross a limit of medicine or such types of drugs lets take example of alprazolam  a medicine which is used for induce sleep and treat some types of anxiety .when a parson overdose from it may be death occur  from that  from the medicine such types of condition are know as overdose and many other drugs used as a antidotes


age effect    

overdose affect all age human

Incidence/prevalence

Common presentation to A&E, commonest cause of
medical admission of teenagers.

Clinical features

Acute poisoning should be considered in any patient presenting with
altered levels of consciousness; however, the
vast majority of patients who present are conscious. The
patient or carers may be able to give a history and bring
the containers or tablets. A full physical examination
should be made.

pathophysiology 

Central nervous system: Impaired consciousness,
Occasionally transient gastrointestinal upset, confusion,
dizziness and ataxia may occur
world.
Severe toxicity (usually an idiosyncratic response,
rather than dose-related) includes cardiac arrhythmias,
hypotension and shock, hyponatraemia,
seizures, increasing confusion and loss of consciousness.
A history should be taken of recent and previous
recreational drug use, including methods of administration,
alcohol intake. A psychiatric and social history
should be taken

Complications

Deaths: These appear to be due to cardiac arrhythmias,
fulminant liver failure and neuroleptic malignant syndrome,
which may cause acute renal failure, disseminated
intravascular coagulation and metabolic acidosis.
Neuropsychiatric complications include memory and
concentration loss, insomnia, hallucinations and flashbacks.

how to deal when overdose 

In all cases, ECG, U&Es, LFTS and creatinine kinase (CK)
should be performed

how to Manage

In severe toxicity, initial management includes ensuring
a clear airway, and ventilation if needed.
1 All patients should have cardiac, pulse, blood pressure
and temperature monitoring.
2 Diazepam for agitation, anxiety, significant hypertension
and seizures.
3 Continued hypertension is treated with intravenous
glyceryl trinitrate, but in refractory hypertension contact
the NPIS.
4 Symptomatic hyponatraemia is usually treated with
water restriction; however, in coexisting hypotension
normal saline infusion may be required.

Common causes of acute poisoning

Over the counter                          Salicylates, paracetamol, ibuprofen
medicines
Psychotropic drugs

Drugs of abuse
 Opiates, cocaine, ecstasy,
amphetamines, ketamine
Garden Plants,
seeds, mushrooms,
insecticides, organophosphates

 some common Drug and its  Antidotes

Benzodiazepines              Flumazenil
Paracetamol                     N-acetyl cysteine
Opiates                             Naloxone
β-blockers                        Atropine and glucagon
Digoxin                            Digoxin specific antibody

let's take some commen medicine overdosing problems and its solution

Iron overdose

Definition

Accidental or deliberate overdose of iron salts.

pathophysiology 


Iron poisoning is usually seen in childhood and results
from accidental ingestion of iron-containing medications
such as vitamin preparations mistaken for sweets.

Clinical features of iron overdose 

Iron causes acute necrotising gastritis. Patients may develop
nausea, vomiting, abdominal pain and diarrhoea.
In severe poisoning acute upper gastrointestinal bleeding,
convulsions and metabolic acidosis may occur. Late
signs in severe overdose include hypotension, coma, hypoglycaemia
and hepatocellular necrosis.

how to investigate 

A serum iron level (ideally at 4 hours after ingestion) is
the best laboratory measure of severity. Abdominal Xray
may show radio-opaque tablets present in the stomach
or small bowel if taken within 2 hours of ingestion.
A raised neutrophil count and serum glucose suggests
toxicity. LFTs and blood gas measurements should be
performed.

Complications and risk factor 

Gastrointestinal perforation or infarction.

Management

In severe poisoning (unconscious or hypotension)
intravenous fluids and desferrioxamine (a chelating
agent for iron) should be commenced immediately
before waiting for serum iron levels. Gastrointestinal
haemorrhage may require blood replacement and
metabolic acidosis should be corrected. Liver and renal
support may be required.
In absence of symptoms, serum levels are monitored
every 2 hours until levels fall or symptoms develop.
Symptomatic patients with moderate (3–5 mg/L or
55–90 μmol/L) or severe (>5 mg/L or 90 μmol/L)
poisoning may require treatment with i.v. desferrioxamine.
Patients who have not developed symptoms
by 6 hours following ingestion are unlikely to have
had a significant overdose and do not require further
monitoring.
Within an hour of ingestion of large doses of iron,
gastric lavage or endoscopic removal of tablets may be
performed.

Tricyclic antidepressant overdose

Definition

Accidental or deliberate overdose of tricyclic antidepressant
drugs.
Incidence/prevalence
Almost 1.8% of poisoning cases, but 18% of all deaths
by poisoning.

Pathophysiology

Tricyclic antidepressants have anticholinergic, alpha adrenergic
blocking, and adrenergic uptake inhibiting
properties. They also have a quinidine like effect on the
myocardium. Alcohol and other psychotropic drugs increase
the toxicity.

Clinical features

Common features include hot, dry skin, dry mouth,
dilated pupils and urinary retention.
Cardiovascular consequences include sinus tachycardia,
vasodilation, hypotension and cardiac arrhythmias.
Neurological consequences include ataxia, nystagmus
and altered levels of consciousness including coma,
hypothermia and respiratory depression. There may
be increased tone, increased deep tendon reflexes and
extensor plantar responses. If the patient is comatose,
all reflexes may be absent.
Convulsions occur in over 5%.
Confusion, agitation and visual hallucinations may
occur during recovery.

Complications

Pulmonary oedema due to decreased cardiac contractility
and fluid overload.
Investigations
Arterial blood gases to check both pH and bicarbonate
levels. ECG may reveal prolonged PR interval and QRS
complexes or bizarre changes in severe toxicity.ContinuousECGmonitoring
is essential. U&Es and urine output
should be monitored

Lithium overdose

Definition

Lithium poisoning usually results from chronic drug accumulation,
accidental or deliberate overdose of lithium
carbonate

pathophysiology

Lithium has a narrow therapeutic index (the levels at
which it becomes toxic are only marginally higher than
those needed to be therapeutic). Impaired renal excretion
such as with dehydration or renal failure may induce
toxicity, as may concomitant use of nonsteroidal
anti-inflammatory drugs or ACE-inhibitors

Clinical features

There is good correlation between symptoms and plasma
concentration.
Mild toxicity: Nausea, diarrhoea, blurred vision,
polyuria, fine resting tremor, muscle weakness and
drowsiness.
Moderate toxicity: Confusion, faints, muscle fasciculation,
hyperreflexia, myoclonus, incontinence, restlessness
or decreased consciousness.
Severe toxicity: Depressed conscious level, convulsions,
arrhythmias including conduction block, hypotension
and renal failure.

Investigations

Serum Lithium levels should be measured if chronic toxicity
is suspected. Therapeutic concentration between 0.4
and 1 mmol/L. Serious toxicity and significant mortality
in levels above 2 mmol/L. In acute overdose, levels
should be taken 6 hours post-ingestion and 6–12 hourly
thereafter. Symptomatic patients require ECG monitoring.

Management

In chronic accumulation, stopping lithium is often all
that is needed to alleviate symptoms; however, patients
may require other treatments for bipolar disorder.
In acute severe toxicity, airway and ventilatory support
may be required if unconscious. All patients should be
observed for a minimum of 24 hours post-ingestion.
Ensure adequate hydration and correct any electrolyte
imbalance. In refractory hypotension, inotropes may

Prognosis

The mortality in chronic poisoning is 9%, but as high
as 25% in acute overdose. Clinical symptoms may persist
after the serumlithium levels have fallen and 10% of
patients with chronic poisoning have long-term neurological
sequelae.

see also

All about caffeine you need to know are here