Sunday, 18 June 2017

Vaccines for salmonella typhi precautions usage and effect

  • Typhoid fever is caused by Salmonella typhi, an enteric gram-negative rod.
  • The disease is common in developing countries with poor sanitation.
  • Typhoid presents with fever, GI symptoms and leukopenia. It can be fatal if left untreated.


  • Injectable: Polysaccharide vaccine
  • Oral: Live attenuated bacterial vaccine


  • Exact figures from large studie
  • s are lacking, however, reported efficacy from various studies is in the range of 50-75%.
  • It is important for travelers to recognize that getting vaccinated is not a substitute for being careful about edibles and beverages because the vaccine is not 100% effective.


Routine Vaccination:
Typhoid vaccination is usually not done in developed countries like US where Typhoid is relatively rare.
While Typhoid endemic countries especially in Asia will likely benefit from routine immunization against Typhoid, not many countries have included the vaccine in their routine immunization programs.
At Risk Groups:
Vaccination is recommended for the following groups of people who are likely to be exposed to S. typhi.
  • Travelers to typhoid endemic areas. Ty21a vaccine should be administered at least 1 weak before expected exposure. Vi capsular vaccine should be administered at least 2 weeks before expected exposure.
  • Close contacts of a documented typhoid carrier.
  • Lab workers who may be exposed to S. typhi cultures or other possibly contaminated material.
Schedule:
  • Vi capsular: single dose is required given IM. A booster dose is recommended every two years if the person continues to remain at risk. The vaccine is not for use in children younger than 2 years.
  • Ty21a vaccine: 4 doses taken orally on alternate days (day 0, 2, 4, and 6). The whole course of 4 doses is to be repeated every 5years if the person continues to remain at risk. Not to be used in children younger than 6 years.


Contraindications:
  • Both vaccines are contraindicated in patients who’ve severe allergic reaction to a previous dose of the vaccine, or who are allergic to any component of the vaccine.
  • None of the vaccines is recommended for use in children younger than 2 years.
  • Ty21a vaccine should be avoided in pregnancy and immunocompromised individuals as it is a live-attenuated vaccine. Vi capsular vaccine may be used in pregnant women only if clearly indicated.
Precautions:
  • Antimicrobial drugs may interfere with the activity of Ty21a vaccine. Therefore it should not be given until at least 3 days after the last antibiotic dose.
  • Vaccination preferably should be delayed in a person with acute febrile illness or acute gastroenteritis.

Thursday, 15 June 2017

Rubella vaccines uses and treatment

Rubella or German Measles is caused by Rubella virus, an RNA virus of the Togaviridae family.It most commonly affects young children. If contracted during pregnancy, Rubella can cause serious birth defects in the newborn.

Rubella Vaccine

Rubella vaccine is used in combination with Measles and Mumps vaccines as MMR. Another vaccine available is MMRV (Measles, mumps, rubella, and varicella).See Measles vaccine for information regarding MMR and MMRV.

Usage

Pregnant women: All women of child-bearing age need protection against Rubella, because it can cause serious fetal congenital anomalies including cardiac defects.

See Measles vaccine for use of MMR/MMRV vaccine during pregnancy and other uses.

Precautions

See Measles Vaccine.

Saturday, 3 June 2017

Adjustment disoders treatment causes and information

DEFINITION

Work problems, going away to school, an illness — any number of life changes can cause stress. Most of the time, people adjust to such changes within a few months. But if you continue to feel down or self-destructive, you may have an adjustment disorder.

An adjustment disorder is a type of stress-related mental illness. You may feel anxious or depressed, or even have thoughts of suicide. Your normal daily routines may feel overwhelming. Or you may make reckless decisions. In essence, you have a hard time adjusting to change in your life, and it has serious consequences.

You don't have to tough it out on your own, though. Adjustment disorder treatment — usually brief — is likely to help you regain your emotional footing.

SYMPTOMS

Adjustment disorders symptoms vary from person to person. The symptoms you have may be different from those of someone else with an adjustment disorder. But for everyone, symptoms of an adjustment disorder begin within three months of a stressful event in your life.

Emotional symptoms of adjustment disorders

Signs and symptoms of adjustment disorder may affect how you feel and think about yourself or life, including:

SadnessHopelessnessLack of enjoymentCrying spellsNervousnessJitterinessAnxiety, which may include separation anxietyWorryDesperationTrouble sleepingDifficulty concentratingFeeling overwhelmedThoughts of suicide

Behavioral symptoms of adjustment disorders

Signs and symptoms of adjustment disorder may affect your actions or behavior, such as:

FightingReckless drivingIgnoring billsAvoiding family or friendsPerforming poorly in school or at workSkipping schoolVandalizing property

Length of symptoms

How long you have symptoms of an adjustment disorder also can vary:

6 months or less (acute). In these cases, symptoms should ease once the stressor is removed. Brief professional treatment may help symptoms disappear.More than 6 months (chronic). In these cases, symptoms continue to bother you and disrupt your life. Professional treatment may help symptoms improve and prevent the condition from continuing to get worse.

Stressful events

One or more stressful life events may put you at risk of developing an adjustment disorder. It may involve almost any type of stressful event in your life. Both positive and negative events can cause extreme stress. Some common examples include:

Being diagnosed with a serious illnessProblems in schoolDivorce or relationship breakupJob lossHaving a babyFinancial problemsPhysical assaultSurviving a disasterRetirementDeath of a loved oneGoing away to school

In some cases, people who face an ongoing stressful situation — such as living in a crime-ridden neighborhood — can reach a breaking point and develop an adjustment disorder.

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TESTS AND DIAGNOSIS

Adjustment disorders are diagnosed based on signs and symptoms and a thorough psychological evaluation. To be diagnosed with adjustment disorder, you must meet criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM). This manual, published by the American Psychiatric Association, is used by mental health professionals to diagnose mental conditions and by insurance companies to reimburse for treatment.

For an adjustment disorder to be diagnosed, several criteria must be met, including:

Having emotional or behavioral symptoms within three months of a specific stressor occurring in your lifeExperiencing more stress than would normally be expected in response to the stressor, or having stress that causes significant problems in your relationships, at work or at school — or having both of these criteriaAn improvement of symptoms within six months after the stressful event endsThe symptoms are not the result of another diagnosis

Types of adjustment disorders

Your doctor may ask detailed questions about how you feel and how you spend your time. This will help pinpoint which type of adjustment disorder you have. There are six main types. Although they're all related, each type has certain signs and symptoms:

Adjustment disorder with depressed mood. Symptoms mainly include feeling sad, tearful and hopeless, and experiencing a lack of pleasure in the things you used to enjoy.Adjustment disorder with anxiety. Symptoms mainly include nervousness, worry, difficulty concentrating or remembering things, and feeling overwhelmed. Children who have adjustment disorder with anxiety may strongly fear being separated from their parents and loved ones.Adjustment disorder with mixed anxiety and depressed mood. Symptoms include a mix of depression and anxiety.Adjustment disorder with disturbance of conduct. Symptoms mainly involve behavioral problems, such as fighting or reckless driving. Youths may skip school or vandalize property.Adjustment disorder with mixed disturbance of emotions and conduct. Symptoms include a mix of depression and anxiety as well as behavioral problems.Adjustment disorder unspecified. Symptoms don't fit the other types of adjustment disorders, but often include physical problems, problems with family or friends, or work or school problems.

TREATMENTS AND DRUGS

Most people find treatment of adjustment disorder helpful, and they often need only brief treatment. Others may benefit from longer treatment. There are two main types of treatment for adjustment disorder — psychotherapy and medications.

Psychotherapy

The main treatment for adjustment disorders is psychotherapy, also called counseling or talk therapy. You may attend individual therapy, group therapy or family therapy. Therapy can provide emotional support and help you get back to your normal routine. It can also help you learn why the stressful event affected you so much. As you understand more about this connection, you can learn healthy coping skills to help you deal with other stressful events that may arise.

Medications

In some cases, medications may help, too. Medications can help with such symptoms as depression, anxiety and suicidal thoughts. Antidepressants and anti-anxiety medications are the medications most often used to treat adjustment disorders. As with therapy, you may need medications only for a few months, but don't stop taking any medication without talking with your doctor first. If stopped suddenly, some medications, such as certain antidepressants, may cause withdrawal symptoms.

Thursday, 1 June 2017

Scabies symptom casuse diagnoses and treatment by drugs

DEFINITION of scabies

Scabies is an itchy skin condition caused by a tiny burrowing mite called Sarcoptes scabiei. The presence of the mite leads to intense itching in the area of its burrows. The urge to scratch may be especially strong at night.

Scabies is contagious and can spread quickly through close physical contact in a family, child care group, school class or nursing home. Because of the contagious nature of scabies, doctors often recommend treatment for entire families or contact groups to eliminate the mite.

Take heart in that scabies is readily treated. Medications applied to your skin kill the mites that cause scabies and their eggs, although you may still experience some itching for several weeks.

SYMPTOMS

Scabies signs and symptoms include:

Itching, often severe and usually worse at nightThin, irregular burrow tracks made up of tiny blisters or bumps on your skin

The burrows or tracks typically appear in folds of your skin. Though almost any part of your body may be involved, in adults scabies is most often found:

Between fingersIn armpitsAround your waistAlong the insides of wristsOn your inner elbowOn the soles of your feetAround breastsAround the male genital areaOn buttocksOn kneesOn shoulder blades

In children, common sites of infestation include the:

ScalpFaceNeckPalms of the handsSoles of the feet

When to see a doctor

Talk to your doctor if you have signs and symptoms that may indicate scabies.

Many skin conditions, such as dermatitis or eczema, are associated with itching and small bumps on the skin. Your doctor can help determine the exact cause and ensure you receive proper treatment. Bathing and over-the-counter preparations won't eliminate scabies.

CAUSES

The eight-legged mite that causes scabies in humans is microscopic. The female mite burrows just beneath your skin and produces a tunnel in which it deposits eggs. The eggs hatch in three to four days, and the mite larvae work their way to the surface of your skin, where they mature and can spread to other areas of your skin or to the skin of other people. The itching of scabies results from your body's allergic reaction to the mites, their eggs and their waste.

Close physical contact and, less often, sharing clothing or bedding with an infected person can spread the mites.

Dogs, cats and humans all are affected by their own distinct species of mite. Each species of mite prefers one specific type of host and doesn't live long away from that preferred host. So humans may have a temporary skin reaction from contact with the animal scabies mite. But people are unlikely to develop full-blown scabies from this source, as they might from contact with the human scabies mite.

COMPLICATIONS

Vigorous scratching can break your skin and allow a secondary bacterial infection, such as impetigo, to occur. Impetigo is a superficial infection of the skin that's caused most often by staph (staphylococci) bacteria or occasionally by strep (streptococci) bacteria.

A more severe form of scabies, called crusted scabies, may affect certain high-risk groups, including:

People with chronic health conditions that weaken the immune system, such as HIV or chronic leukemiaPeople who are very ill, such as people in hospitals or nursing facilitiesOlder people in nursing homes

Crusted scabies tends to be crusty and scaly, and cover large areas of the body. It's very contagious and can be hard to treat.

PREPARING FOR YOUR APPOINTMENT

Make an appointment with your family doctor or pediatrician if you or your child has signs and symptoms common to scabies.

Here's some information to help you get ready for your appointment, and know what to expect from your doctor.

Information to gather in advance

List any signs or symptoms you or your child has had, and for how long.List any possible sources of infection, such as other family members who have had a visible or itchy rash.Write down key medical information, including any other health problems and the names of any medications you or your child is taking.Write down questions you want to be sure to ask your doctor.

Below are some basic questions to ask your doctor about scabies.

What is the most likely cause of these signs and symptoms?Are there any other possible causes?What treatment approach do you recommend?How soon do you expect symptoms to improve with treatment?When will you see me or my child to determine whether the treatment you've recommended is working?Are there any home remedies or self-care steps that could help relieve symptoms?Am I or my child contagious? For how long?What steps should be taken to reduce the risk of infecting others?

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over any points you want to talk about in-depth. Your doctor may ask:

What signs and symptoms have you noticed?When did you first notice these signs and symptoms?Have these signs and symptoms gotten worse over time?If you or your child has a visible rash, what parts of the body are affected?Has anyone else with whom you have frequent, close contact had a rash, an itch or both within the last several weeks?Are you currently pregnant or nursing?Are you or your child currently being treated or have you recently been treated for any other medical conditions?What medications are you or your child currently taking, including prescription and over-the-counter drugs, vitamins and supplements?Is your child in child care?

What you can do in the meantime

In the time leading up to your appointment, try at-home and over-the-counter (OTC) remedies to help reduce itching. Cool water, antihistamines and calamine lotion may provide some relief. Ask your doctor what OTC medications and lotions are safe for your baby or child.

TESTS AND DIAGNOSIS

To diagnose scabies, your doctor examines your skin, looking for signs of mites, including the characteristic burrows. When your doctor locates a mite burrow, he or she may take a scraping from that area of your skin to examine under a microscope. The microscopic examination can determine the presence of mites or their eggs.

TREATMENTS AND DRUGS

Scabies treatment involves eliminating the infestation with medications. Several creams and lotions are available. You usually apply the medication over all your body, from your neck down, and leave the medication on for at least eight hours. A second treatment is needed if new burrows and rash appear.

Because scabies spreads so easily, your doctor may recommend treatment for all family members and other close contacts, even if they show no signs of scabies infestation.

Medications commonly prescribed for scabies include:

Permethrin 5 percent (Elimite). Your doctor may recommend that you apply this cream — which contains chemicals that kill scabies mites and their eggs — twice, with a week or so between each application. Permethrin is generally considered safe for children and adults of all ages, including women who are pregnant or nursing.Lindane. This medication — also a chemical treatment — is available as a cream, lotion and shampoo. This medication isn't safe for children younger than age 2 years, women who are pregnant or nursing, or people with weakened immune systems.Crotamiton (Eurax). This nonchemical medication is applied once a day for two to five days. Your doctor may recommend it if your baby has scabies.

Although these medications kill the mites promptly, you may find that the itching doesn't stop entirely for several weeks.

Doctors sometimes prescribe the oral medication ivermectin (Stromectol) for people with altered immune systems, for people who have crusted scabies, or for people who don't respond to the prescription lotions and creams.

LIFESTYLE AND HOME REMEDIES

To prevent re-infestation and to prevent the mites from spreading to other people, take these steps:

Clean all clothes and linen. Use hot, soapy water to wash all clothing, towels and bedding you used at least three days before treatment. Dry with high heat. Dry-clean items you can't wash at home.Starve the mites. Consider placing items you can't wash in a sealed plastic bag and leaving it in an out-of-the-way place, such as in your garage, for a couple of weeks. Mites die if they don't eat for a week. caused by a tiny burrowing mite called Sarcoptes scabiei. The presence of the mite leads to intense itching in the area of its burrows. The urge to scratch may be especially strong at night.

Scabies is contagious and can spread quickly through close physical contact in a family, child care group, school class or nursing home. Because of the contagious nature of scabies, doctors often recommend treatment for entire families or contact groups to eliminate the mite.

Take heart in that scabies is readily treated. Medications applied to your skin kill the mites that cause scabies and their eggs, although you may still experience some itching for several weeks.

SYMPTOMS

Scabies signs and symptoms include:

Itching, often severe and usually worse at nightThin, irregular burrow tracks made up of tiny blisters or bumps on your skin

The burrows or tracks typically appear in folds of your skin. Though almost any part of your body may be involved, in adults scabies is most often found:

Between fingersIn armpitsAround your waistAlong the insides of wristsOn your inner elbowOn the soles of your feetAround breastsAround the male genital areaOn buttocksOn kneesOn shoulder blades

In children, common sites of infestation include the:

ScalpFaceNeckPalms of the handsSoles of the feet

When to see a doctor

Talk to your doctor if you have signs and symptoms that may indicate scabies.

Many skin conditions, such as dermatitis or eczema, are associated with itching and small bumps on the skin. Your doctor can help determine the exact cause and ensure you receive proper treatment. Bathing and over-the-counter preparations won't eliminate scabies.

CAUSES

The eight-legged mite that causes scabies in humans is microscopic. The female mite burrows just beneath your skin and produces a tunnel in which it deposits eggs. The eggs hatch in three to four days, and the mite larvae work their way to the surface of your skin, where they mature and can spread to other areas of your skin or to the skin of other people. The itching of scabies results from your body's allergic reaction to the mites, their eggs and their waste.

Close physical contact and, less often, sharing clothing or bedding with an infected person can spread the mites.

Dogs, cats and humans all are affected by their own distinct species of mite. Each species of mite prefers one specific type of host and doesn't live long away from that preferred host. So humans may have a temporary skin reaction from contact with the animal scabies mite. But people are unlikely to develop full-blown scabies from this source, as they might from contact with the

TESTS AND DIAGNOSIS

To diagnose scabies, your doctor examines your skin, looking for signs of mites, including the characteristic burrows. When your doctor locates a mite burrow, he or she may take a scraping from that area of your skin to examine under a microscope. The microscopic examination can determine the presence of mites or their eggs.

TREATMENTS AND DRUGS

Scabies treatment involves eliminating the infestation with medications. Several creams and lotions are available. You usually apply the medication over all your body, from your neck down, and leave the medication on for at least eight hours. A second treatment is needed if new burrows and rash appear.

Because scabies spreads so easily, your doctor may recommend treatment for all family members and other close contacts, even if they show no signs of scabies infestation.

Medications commonly prescribed for scabies include:

Permethrin 5 percent (Elimite). Your doctor may recommend that you apply this cream — which contains chemicals that kill scabies mites and their eggs — twice, with a week or so between each application. Permethrin is generally considered safe for children and adults of all ages, including women who are pregnant or nursing.Lindane. This medication — also a chemical treatment — is available as a cream, lotion and shampoo. This medication isn't safe for children younger than age 2 years, women who are pregnant or nursing, or people with weakened immune systems.Crotamiton (Eurax). This nonchemical medication is applied once a day for two to five days. Your doctor may recommend it if your baby has scabies.

Although these medications kill the mites promptly, you may find that the itching doesn't stop entirely for several weeks.

Doctors sometimes prescribe the oral medication ivermectin (Stromectol) for people with altered immune systems, for people who have crusted scabies, or for people who don't respond to the prescription lotions and creams.

see also

All about caffeine you need to know are here